Gif Central boasts hundreds of funny animated gifs. Only the best of the best make it onto this site, with most of them having an accompanying source. No tumblr-esque one-second-long disappointments. No obscure titles or descriptions.
This is an animated gif of Ron Burgundy squinting and saying "That doesn't make any sense". This is from the movie Anchorman (2004). Burgundy is played by actor Will Ferrell, who is from Irvine, California.